Persulfate activation is a research area focused on enhancing the effectiveness of persulfate-based oxidation processes for the treatment of organic contaminants in water and soil. Persulfate (S2O8^2-) is a powerful oxidizing agent that can degrade a wide range of organic pollutants, but its activation is necessary to accelerate the reaction rates and improve the efficiency of the oxidation process. Activation methods typically involve the addition of a catalyst, such as transition metals, iron-based materials, or heat, to generate sulfate radicals (SO4•-) that can react with the target contaminants. Research in this area aims to develop novel activation strategies, optimize reaction conditions, and understand the mechanisms involved in persulfate activation for environmental remediation applications.